Professor Edik Rafailov (Coordinator), Dr Sergei Sokolovski (both AIPT) and Dr Rhein Parri (LHS) has won an enormously prestigious award from the EC Future and Emerging Technology (FET) Scheme. The scheme published success rate is below 5%, making it amongst the toughest in the H2020 suite of schemes. The Proposal, NEUROPA attracting €3.6 million, with €977k going to the Aston team. The NEUROPA consortium has assembled to develop a conceptually novel non-invasive theranostic approach. We will develop a non-invasive system, which modulates long-term activity in specific cortico-sub-cortical networks implicated in specific brain disorders. This will be achieved by two-photon activation of novel phytochrome actuators that control the expression of genes involved in synaptic plasticity. The resulting increase in cortical and subcortical network activity will lead to the long term alleviation of dysfunction using novel phytoptogenetics technology.